Background: Patient-derived xenograft (PDX) models have been a focus of attention
because they closely resemble the tumor features of patients and retain the molecular and …

Simple Summary The rate of total tumor engraftment of patient-derived xenografts is 50% in
cervical cancer. These cancers retain their histopathological characteristics. The gene …

Background Recurrent or metastatic cervical cancer (r/m CC) often has poor prognosis
owing to its limited treatment options. The development of novel therapeutic strategies has …

Apparent diffusion coefficient (ADC) values derived from diffusion-weighted magnetic
resonance imaging (DW-MRI) are known to reflect the cellular environment of biological …

Human papillomavirus (HPV) is predominantly associated with HPV-related cancers,
however, the precise mechanisms underlying the HPV-host epigenetic architectures in HPV …

Background: Cervical cancer is a world-wide problem that requires transformative
therapeutic strategies. We have previously developed patient-derived orthotopic xenograft …

Background Abnormalities in the tumor microenvironment are associated with resistance to
treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical …

Preclinical studies have suggested that interstitial fluid pressure (IFP) is uniformly elevated
in the central region of tumors, whereas clinical studies have revealed that IFP may vary …

Purpose This study had a dual purpose: to investigate (1) whether bevacizumab can change
the microvasculature and oxygenation of cervical carcinomas and (2) whether any changes …

Four patient-derived xenograft (PDX) models (BK-12, ED-15, HL-16, LA-19) of carcinoma of
the uterine cervix have been developed in our laboratory, and their stability during serial …