Molecular docking: shifting paradigms in drug discovery
L Pinzi, G Rastelli - International journal of molecular sciences, 2019 - mdpi.com
Molecular docking is an established in silico structure-based method widely used in drug
discovery. Docking enables the identification of novel compounds of therapeutic interest …
discovery. Docking enables the identification of novel compounds of therapeutic interest …
Autophagy as a molecular target for cancer treatment
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety
M Ekor - Frontiers in pharmacology, 2014 - frontiersin.org
The use of herbal medicinal products and supplements has increased tremendously over
the past three decades with not less than 80% of people worldwide relying on them for some …
the past three decades with not less than 80% of people worldwide relying on them for some …
Targeting drug chemo-resistance in cancer using natural products
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …
Biosynthesis and biotechnological production of ginsenosides
Medicinal plants are essential for improving human health, and around 75% of the
population in developing countries relies mainly on herb-based medicines for health care …
population in developing countries relies mainly on herb-based medicines for health care …
Anticancer effects of ginsenoside Rg3
M Sun, Y Ye, L Xiao, X Duan… - International …, 2017 - spandidos-publications.com
Cancer is a life-threatening disease with an alarmingly increased annual mortality rate
globally. Although various therapies are employed for cancer, the final effect is not …
globally. Although various therapies are employed for cancer, the final effect is not …
Saponins in cancer treatment: Current progress and future prospects
Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming
nature. Different saponins have been characterized and purified and are gaining attention in …
nature. Different saponins have been characterized and purified and are gaining attention in …
Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy
Y Zhu, J Liang, C Gao, A Wang, J Xia, C Hong… - Journal of Controlled …, 2021 - Elsevier
Liposomes have been widely used for targeted drug delivery. However, nonselective
distribution, low blood-brain barrier penetration, and the disadvantages of cholesterol …
distribution, low blood-brain barrier penetration, and the disadvantages of cholesterol …
[HTML][HTML] Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions
Ginseng has gained its popularity as an adaptogen since ancient days because of its
triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and …
triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and …
The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells
JH Lorent, J Quetin-Leclercq… - Organic & biomolecular …, 2014 - pubs.rsc.org
Saponins, amphiphiles of natural origin with numerous biological activities, are widely used
in the cosmetic and pharmaceutical industry. Some saponins exhibit relatively selective …
in the cosmetic and pharmaceutical industry. Some saponins exhibit relatively selective …