Molecular docking: shifting paradigms in drug discovery

L Pinzi, G Rastelli - International journal of molecular sciences, 2019 - mdpi.com
Molecular docking is an established in silico structure-based method widely used in drug
discovery. Docking enables the identification of novel compounds of therapeutic interest …

Autophagy as a molecular target for cancer treatment

NM Kocaturk, Y Akkoc, C Kig, O Bayraktar… - European Journal of …, 2019 - Elsevier
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety

M Ekor - Frontiers in pharmacology, 2014 - frontiersin.org
The use of herbal medicinal products and supplements has increased tremendously over
the past three decades with not less than 80% of people worldwide relying on them for some …

Targeting drug chemo-resistance in cancer using natural products

WH Talib, AR Alsayed, M Barakat, MI Abu-Taha… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Biosynthesis and biotechnological production of ginsenosides

YJ Kim, D Zhang, DC Yang - Biotechnology advances, 2015 - Elsevier
Medicinal plants are essential for improving human health, and around 75% of the
population in developing countries relies mainly on herb-based medicines for health care …

Anticancer effects of ginsenoside Rg3

M Sun, Y Ye, L Xiao, X Duan… - International …, 2017 - spandidos-publications.com
Cancer is a life-threatening disease with an alarmingly increased annual mortality rate
globally. Although various therapies are employed for cancer, the final effect is not …

Saponins in cancer treatment: Current progress and future prospects

OO Elekofehinti, O Iwaloye, F Olawale, EO Ariyo - Pathophysiology, 2021 - mdpi.com
Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming
nature. Different saponins have been characterized and purified and are gaining attention in …

Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy

Y Zhu, J Liang, C Gao, A Wang, J Xia, C Hong… - Journal of Controlled …, 2021 - Elsevier
Liposomes have been widely used for targeted drug delivery. However, nonselective
distribution, low blood-brain barrier penetration, and the disadvantages of cholesterol …

[HTML][HTML] Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions

P Mohanan, S Subramaniyam, R Mathiyalagan… - Journal of Ginseng …, 2018 - Elsevier
Ginseng has gained its popularity as an adaptogen since ancient days because of its
triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and …

The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells

JH Lorent, J Quetin-Leclercq… - Organic & biomolecular …, 2014 - pubs.rsc.org
Saponins, amphiphiles of natural origin with numerous biological activities, are widely used
in the cosmetic and pharmaceutical industry. Some saponins exhibit relatively selective …