Poloxamer hydrogels for biomedical applications

E Russo, C Villa - Pharmaceutics, 2019 - mdpi.com
This review article focuses on thermoresponsive hydrogels consisting of poloxamers which
are of high interest for biomedical application especially in drug delivery for ophthalmic …

Adhesive hydrogels in osteoarthritis: From design to application

WL Duan, LN Zhang, R Bohara… - Military Medical …, 2023 - Springer
Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7%
of the global population and more than 500 million people worldwide. One research frontier …

Thermosensitive hydrogel based on PEO–PPO–PEO poloxamers for a controlled in situ release of recombinant adeno‐associated viral vectors for effective gene …

H Madry, L Gao, A Rey‐Rico, JK Venkatesan… - Advanced …, 2020 - Wiley Online Library
Advanced biomaterial‐guided delivery of gene vectors is an emerging and highly attractive
therapeutic solution for targeted articular cartilage repair, allowing for a controlled and …

Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair

M Cucchiarini, H Madry - Nature Reviews Rheumatology, 2019 - nature.com
Articular cartilage defects are prevalent and are potentially involved in the initiation of
osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents …

Nanogels for regenerative medicine

MA Grimaudo, A Concheiro… - Journal of Controlled …, 2019 - Elsevier
Nanogels have been widely explored for drug delivery, but their applications in the tissue
engineering field are still quite recent. Regenerative medicine also demands controlled …

[HTML][HTML] Poloxamer-chitosan-based Naringenin nanoformulation used in brain targeting for the treatment of cerebral ischemia

N Ahmad, R Ahmad, FJ Ahmad, W Ahmad… - Saudi Journal of …, 2020 - Elsevier
Objective Here, the aim is to improve the bioavailability of Naringenin (NRG) in brain and to
establish the highest remedial benefit from a novel anti-ischemic medicine ie NRG. Methods …

Injectable hydrogels and nanocomposite hydrogels for cartilage regeneration

O Jeznach, D Kołbuk… - Journal of Biomedical …, 2018 - Wiley Online Library
Cartilage loss due to age‐related degeneration and mechanical trauma is a significant and
challenging problem in the field of surgical medicine. Unfortunately, cartilage tissue can be …

[HTML][HTML] Recent advances in polymeric biomaterials-based gene delivery for cartilage repair

R Yang, F Chen, J Guo, D Zhou, S Luan - Bioactive materials, 2020 - Elsevier
Untreated articular cartilage damage normally results in osteoarthritis and even disability
that affects millions of people. However, both the existing surgical treatment and tissue …

Materials promoting viral gene delivery

K Kaygisiz, CV Synatschke - Biomaterials Science, 2020 - pubs.rsc.org
Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …

A novel indomethacin/methotrexate/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic …

N Yin, X Tan, H Liu, F He, N Ding, J Gou, T Yin, H He… - Nanoscale, 2020 - pubs.rsc.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory cell
infiltration, and cartilage and bone disruption, which ultimately leads to loss of joint function …