Protein bioinformatics databases and resources
Many publicly available data repositories and resources have been developed to support
protein-related information management, data-driven hypothesis generation, and biological …
protein-related information management, data-driven hypothesis generation, and biological …
Importance of enzyme specificity and stability for the application of proteases in greener industrial processing-a review
Industries are in great need for process-apt proteases due to environmental concerns. But
the major bottlenecks in the use of enzymes in industrial processes are their lack of …
the major bottlenecks in the use of enzymes in industrial processes are their lack of …
Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors
Abstract The MEROPS database (http://merops. sanger. ac. uk) is an integrated source of
information about peptidases, their substrates and inhibitors, which are of great relevance to …
information about peptidases, their substrates and inhibitors, which are of great relevance to …
PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites
The ability to catalytically cleave protein substrates after synthesis is fundamental for all
forms of life. Accordingly, site-specific proteolysis is one of the most important post …
forms of life. Accordingly, site-specific proteolysis is one of the most important post …
Proteolytic post-translational modification of proteins: proteomic tools and methodology
LD Rogers, CM Overall - Molecular & Cellular Proteomics, 2013 - ASBMB
Proteolytic processing is a ubiquitous and irreversible post-translational modification
involving limited and highly specific hydrolysis of peptide and isopeptide bonds of a protein …
involving limited and highly specific hydrolysis of peptide and isopeptide bonds of a protein …
Microbial and fungal protease inhibitors—current and potential applications
Proteolytic enzymes play essential metabolic and regulatory functions in many biological
processes and also offer a wide range of biotechnological applications. Because of their …
processes and also offer a wide range of biotechnological applications. Because of their …
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
Proteases constitute the largest enzyme family, yet their biological roles are obscured by our
rudimentary understanding of their cellular substrates. There are 12 human caspases that …
rudimentary understanding of their cellular substrates. There are 12 human caspases that …
The Degradome database: expanding roles of mammalian proteases in life and disease
JG Pérez-Silva, Y Espanol, G Velasco… - Nucleic acids …, 2016 - academic.oup.com
Since the definition of the degradome as the complete repertoire of proteases in a given
organism, the combined effort of numerous laboratories has greatly expanded our …
organism, the combined effort of numerous laboratories has greatly expanded our …
SheddomeDB 2023: a revision of an ectodomain shedding database based on a comprehensive literature review and online resources
WY Huang, KP Wu - Journal of Proteome Research, 2023 - ACS Publications
Ectodomain shedding of membrane proteins is a proteolytic event involved in several
biological phenomena, including inflammation, development, diseases, and cancer …
biological phenomena, including inflammation, development, diseases, and cancer …
Predicting structural susceptibility of proteins to proteolytic processing
EV Matveev, VV Safronov, GV Ponomarev… - International Journal of …, 2023 - mdpi.com
The importance of 3D protein structure in proteolytic processing is well known. However,
despite the plethora of existing methods for predicting proteolytic sites, only a few of them …
despite the plethora of existing methods for predicting proteolytic sites, only a few of them …