Molecular pathogenesis of meningiomas

A Perry, DH Gutmann, G Reifenberger - Journal of neuro-oncology, 2004 - Springer
Meningiomas are common central nervous system tumors that originate from the meningeal
coverings of the brain and the spinal cord. Most meningiomas are slowly growing benign …

Meningioma pathology, genetics, and biology

K Lamszus - Journal of Neuropathology & Experimental …, 2004 - academic.oup.com
Over the past 5 to 10 years, important advances were made in the understanding of
meningioma biology. Progress in molecular genetics probably represents the most important …

Genetic and epigenetic alterations in meningiomas

V Galani, E Lampri, A Varouktsi, G Alexiou… - Clinical neurology and …, 2017 - Elsevier
Meningiomas originate from the arachnoid layer of the meninges and divided histologically
into three grades: benign (grade I), atypical (grade II), and malignant meningiomas (grade …

World Health Organization Grades II and III meningiomas are rare in the cranial base and spine

B Sade, A Chahlavi, A Krishnaney, S Nagel… - …, 2007 - journals.lww.com
OBJECTIVE: This study was undertaken to assess a possible relationship between the
tumor location and the incidence of World Health Organization (WHO) Grades II and III …

Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells

K Kaempchen, K Mielke, T Utermark… - Human molecular …, 2003 - academic.oup.com
Schwann cells lacking the tumor-suppressor-protein merlin tend in man to build benign
tumors (schwannoma). We observed that characteristic features of these cells which are …

A practical overview on the molecular biology of meningioma

PD Delgado-López, E Cubo-Delgado… - Current Neurology and …, 2020 - Springer
Abstract Purpose of Review Meningioma is a common intracranial neoplasm currently
classified in 15 histologic subtypes across 3 grades of malignancy. First-choice therapy for …

Mutational spectrum of the NF2 gene: a meta‐analysis of 12 years of research and diagnostic laboratory findings

I Ahronowitz, W Xin, R Kiely, K Sims… - Human …, 2007 - Wiley Online Library
The NF2 tumor suppressor gene on chromosome 22 is a member of the protein 4.1 family of
cytoskeletal elements. A number of single‐and multiple‐tumor phenotypes have been linked …

[HTML][HTML] Comprehensive genetic and epigenetic analysis of sporadic meningioma for macro-mutations on 22q and micro-mutations within the NF2 locus

CM Hansson, PG Buckley, G Grigelioniene… - BMC genomics, 2007 - Springer
Background Meningiomas are the most common intracranial neoplasias, representing a
clinically and histopathologically heterogeneous group of tumors. The neurofibromatosis …

Molecular alterations in meningiomas: Literature review

BJA Pereira, SM Oba-Shinjo, AN de Almeida… - Clinical neurology and …, 2019 - Elsevier
Meningiomas, tumors that originate from meningothelial cells, account for approximately
30% of all new diagnoses of central nervous system neoplasms. According to the 2016 …

Meningiomas: updating basic science, management, and outcome

KJ Drummond, JJ Zhu, PML Black - The neurologist, 2004 - journals.lww.com
Background: Meningiomas are biologically complex and clinically and surgically
challenging. These features, combined with the rewarding potential for cure, make them of …