Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Transport of intracellular components relies on a variety of active and passive mechanisms,
ranging from the diffusive spreading of small molecules over short distances to motor-driven …

During intracellular transport, cellular cargos, such as organelles, vesicles, and proteins, are
transported within cells. Intracellular transport plays an important role in diverse cellular …

Two key prerequisites for glucose-stimulated insulin secretion (GSIS) in β cells are the
proximity of insulin granules to the plasma membrane and their anchoring or docking to the …

Cellular functions such as autophagy, cell signaling, and vesicular trafficking involve the
retrograde transport of motor-driven cargo along microtubules. Typically, newly formed …

Intracellular transport of cargoes in the cell is essential for the organization and functioning
cells, especially those that are large and elongated. The cytoskeletal networks inside large …

A common type of cytoskeletal morphology involves multiple microtubules converging with
their minus ends at the microtubule organizing center (MTOC). The cargo-motor complex will …

In pancreatic beta cells, molecular motors use cytoskeletal polymers microtubules as tracks
for intracellular transport of secretory insulin granules. Beta-cell microtubule network has a …

Transport of intracellular material is a fundamental process observed within the cells of
organisms across all realms of life. While the biology may be vastly different across species …

The spatial localization or sequestering of motile cargo and their dispersal within cells is an
important process in a number of physiological contexts. The morphology of the cytoskeletal …