Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling …
Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …
Targeting SREBP-1-mediated lipogenesis as potential strategies for cancer
Q Zhao, X Lin, G Wang - Frontiers in oncology, 2022 - frontiersin.org
Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …
O-GlcNAcylation in cancer development and immunotherapy
XF He, X Hu, GJ Wen, Z Wang, WJ Lin - Cancer Letters, 2023 - Elsevier
O-linked β-DN-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …
Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope
Flavonoids are natural polyphenolic compounds considered safe, pleiotropic, and readily
available molecules. It is widely distributed in various food products such as fruits and …
available molecules. It is widely distributed in various food products such as fruits and …
Anticancer and apoptosis inducing potential of quercetin against a wide range of human malignancies
Quercetin, a flavonoid, is a dietary component that has attracted the attention of dietitians
and medicinal chemists due to its anticancer potential. It is an antioxidant that has a …
and medicinal chemists due to its anticancer potential. It is an antioxidant that has a …
Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review
Chemotherapy has opened a new window in cancer therapy. However, the resistance of
cancer cells has dramatically reduced the efficacy of chemotherapy. Cisplatin is a …
cancer cells has dramatically reduced the efficacy of chemotherapy. Cisplatin is a …
Therapeutic potentials and targeting strategies of quercetin on cancer cells: Challenges and future prospects
D Sangeetha - Phytomedicine, 2024 - Elsevier
Background Every cell in the human body is vital because it maintains equilibrium and
carries out a variety of tasks, including growth and development. These activities are carried …
carries out a variety of tasks, including growth and development. These activities are carried …
[HTML][HTML] Metabolic strategies for inhibiting cancer development
The tumor microenvironment is a complex mix of cancerous and noncancerous cells
(especially immune cells and fibroblasts) with distinct metabolisms. These cells interact with …
(especially immune cells and fibroblasts) with distinct metabolisms. These cells interact with …
The roles of OGT and its mechanisms in cancer
X Liu, J Wang, Y Xiang, K Wang, D Yan, Y Tong - Cell & Bioscience, 2024 - Springer
Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important
post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to …
post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to …
Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells
Cyclosporin A (CsA) does not only exert a toxic effect on kidney parenchymal cells, but also
protects them against necrotic cell death by inhibiting opening of mitochondrial permeability …
protects them against necrotic cell death by inhibiting opening of mitochondrial permeability …