Monitoring local mosquito populations for insecticide resistance is critical for effective vector-
borne disease control. However, widely used phenotypic assays, which are designed to …

Summary Background Rice fields in Africa are major breeding sites for malaria vectors.
However, when reviewed in the 1990s, in settings where transmission was relatively …

The parasites that cause malaria depend on Anopheles mosquitoes for transmission;
because of this, mosquito population dynamics are a key determinant of malaria risk …

Western Africa is vulnerable to arboviral disease transmission, having recently experienced
major outbreaks of chikungunya, dengue, yellow fever and Zika. However, there have been …

Malaria, one of the greatest historical killers of mankind, continues to claim around half a
million lives annually, with almost all deaths occurring in children under the age of five living …

Background Malaria transmission depends on vector life-history parameters and population
dynamics, and particularly on the survival of adult Anopheles mosquitoes. These dynamics …

Background Adult traits of holometabolous insects such as reproduction and survival can be
shaped by conditions experienced during larval development. These “carry-over” effects …

The spread of synthetic gene drives is often discussed in the context of panmictic
populations connected by gene flow and described with simple deterministic models. Under …

Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian
mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break …

Interest in gene drive technology has continued to grow as promising new drive systems
have been developed in the lab and discussions are moving towards implementing field …