Background Current guidelines recommend oral anticoagulation therapy for patients with
atrial fibrillation (AF) with one or more risk factors for stroke; however, anticoagulation control …

Abbreviations: ALL acute lymphoblastic leukemia; APTT qjactivated partial thromboplastin
time; AT antithrombin; BT Blalock-Taussig; CI confidence interval; CVL central venous line; …

Background Warfarin sodium is widely used and causes bleeding; a review might suggest
the need for regulatory action by the US Food and Drug Administration (FDA). Methods We …

Fluctuations in international normalized ratio values are often ascribed to dietary changes in
vitamin K intake. Here we present a database with vitamin K1 and K2 contents of a wide …

Background Warfarin sodium is a highly efficacious drug, but proper levels of
anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient …

OBJECTIVE To evaluate patients' knowledge of warfarin and its relationship to
anticoagulation control. METHODS From January to March 1999, 122 patients attending the …

ContextControl of oral anticoagulation therapy has been reported to often be inadequate.
Previous retrospective investigations suggest that patients' self-adjustment of oral …

BACKGROUND: Patients receiving chronic warfarin therapy who have poor anticoagulation
control are at increased risk for adverse events. However, it is unknown how adherence to …

Until 1986 to 1987, the estimation of patient compliance with prescribed drug regimens in
ambulatory care relied on methods that were biased either by their subjectivity or by the …

When initiating warfarin therapy, clinicians should avoid loading doses that can raise the
International Normalized Ratio (INR) excessively; instead, warfarin should be initiated with a …