The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …

In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory
system and the dorsal motor nucleus of the vagus nerve before spreading to connected …

Over the past decades, network neuroscience has played a fundamental role in the
understanding of large-scale brain connectivity architecture. Brains, and more generally …

Neuropathological staging studies have suggested that tau pathology spreads through the
brain in Alzheimer's disease (AD) and other tauopathies, but it is unclear how …

Network analysis can provide insight into key organizational principles of brain structure and
help identify structural changes associated with brain disease. Though static differences …

Recent models of Alzheimer's disease progression propose that disease may be transmitted
between brain areas either via local diffusion or long-distance transport via white matter fibre …

Alzheimer's disease, the most common form of dementia, is characterized by the emergence
and spread of senile plaques and neurofibrillary tangles, causing widespread …

Emerging evidence supports the hypothesis that pathogenic protein aggregates associated
with neurodegenerative diseases spread from cell to cell through the brain in a manner akin …