Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Neurodegeneration is one of the driving forces behind the pathogenesis of multiple sclerosis
(MS). Progression without activity, pathopsychological disturbances (cognitive impairment …

Background: The Symbol Digit Modalities Test (SDMT) is increasingly utilized in clinical
trials. A SDMT score change of 4 points is considered clinically important, based on …

Background: The sequence in which cognitive domains become impaired in multiple
sclerosis (MS) is yet to be formally demonstrated. It is unclear whether processing speed …

Background Cognitive reserve (CR) describes an individual's ability to adapt cognitive
processes in response to brain atrophy, and has been reported to explain some of the …

Background: The existence of isolated cognitive relapses (ICRs) in persons with MS (PwMS)
has been debated. Objective: To examine relapses with decline on Symbol Digit Modalities …

Objectives: Determine the validity and reliability of a remote, technician-guided cognitive
assessment for multiple sclerosis (MS), incorporating the Symbol Digit Modalities Test …

Background The relationship between visual impairment and cognitive performance in
multiple sclerosis (MS) remains poorly understood. Objective To determine associations …

Background: Early detection and monitoring of cognitive dysfunction in multiple sclerosis
(MS) may be enabled with smartphone-adapted tests that allow frequent measurements in …

Multiple Sclerosis (MS) is a debilitating disease with typical onset between 20 and 40 years
of age, so the disability associated with this disease, unfortunately, occurs in the prime of life …