Melatonin is well known for its circadian production by the pineal gland, and there is a
growing body of data showing that it is also produced by many other cells and organs …

Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …

The pineal hormone, melatonin (N-acetyl-5-methoxytryptamine), shows potent receptor-
dependent and-independent actions, which participate in blood pressure regulation. The …

We demonstrate that during inflammatory responses the nuclear factor kappa B (NF-κB)
induces the synthesis of melatonin by macrophages and that macrophage-synthesized …

Daily rhythm of melatonin synchronizes the body to the light/dark environmental cycle.
Several hypotheses have been raised to understand the intersections between melatonin …

The pineal gland is a interface between light-dark cycle and shows neuro-endocrine
functions. Melatonin is the primary hormone of pineal gland, secreted at night. The night …

Pineal gland melatonin is the darkness hormone, while extra-pineal melatonin produced by
the gonads, gut, retina, and immune competent cells acts as a paracrine or autocrine …

Objectives To examine the effect of the circadian gene Clock on posttranscriptional function
and pro-inflammatory mechanisms in osteoarthritis (OA). Methods The cartilage from Clock …

Melatonin is synthesized by several tissues besides the pineal gland, and beyond its
regulatory effects in light‐dark cycle, melatonin is a hormone with neuroprotective, anti …

Immune‐pineal axis activation is part of the assembly of immune responses.
Proinflammatory cytokines inhibit the pineal synthesis of melatonin while inducing it in …