[HTML][HTML] Cosmic ionizing radiation: a DNA damaging agent that may underly excess cancer in flight crews

SM Toprani, C Scheibler, I Mordukhovich… - International Journal of …, 2024 - mdpi.com
In the United States, the Federal Aviation Administration has officially classified flight crews
(FC) consisting of commercial pilots, cabin crew, or flight attendants as “radiation workers” …

Radiation-Induced Reactions in the Liver—Modulation of Radiation Effects by Lifestyle-Related Factors—

T Nakajima, Y Ninomiya, M Nenoi - International journal of molecular …, 2018 - mdpi.com
Radiation has a wide variety of effects on the liver. Fibrosis is a concern in medical fields as
one of the acute effects of high-dose irradiation, such as with cancer radiotherapies. Cancer …

Influence of individual radiosensitivity on the adaptive response phenomenon: toward a mechanistic explanation based on the nucleo-shuttling of ATM protein

C Devic, ML Ferlazzo, N Foray - Dose-Response, 2018 - journals.sagepub.com
The adaptive response (AR) phenomenon generally describes a protective effect caused by
a “priming” low dose (d AR) delivered after a period of time (Δ t AR) before a higher …

High-throughput screening platform for nanoparticle-mediated alterations of DNA repair capacity

SM Toprani, D Bitounis, Q Huang, N Oliveira, KW Ng… - ACS …, 2021 - ACS Publications
The potential genotoxic effects of engineered nanomaterials (ENMs) may occur through the
induction of DNA damage or the disruption of DNA repair processes. Inefficient DNA repair …

Role of DNA damage and repair mechanisms in uterine fibroid/leiomyomas: a review

SM Toprani, V Kelkar Mane - Biology of Reproduction, 2021 - academic.oup.com
There has been a significant annual increase in the number of cases of uterine leiomyomas
or fibroids (UF) among women of all races and ages across the world. A fortune is usually …

Radio-adaptive response of base excision repair genes and proteins in human peripheral blood mononuclear cells exposed to gamma radiation

SM Toprani, B Das - Mutagenesis, 2015 - academic.oup.com
Radio-adaptive response is a mechanism whereby a low-dose exposure (priming dose)
induces resistance to a higher dose (challenging dose) thus significantly reducing its …

Printer center nanoparticles alter the DNA repair capacity of human bronchial airway epithelial cells

D Bitounis, Q Huang, SM Toprani, MI Setyawati… - NanoImpact, 2022 - Elsevier
Nano-enabled, toner-based printing equipment emit nanoparticles during operation. The
bioactivity of these nanoparticles as documented in a plethora of published toxicological …

Lack of increased DNA double-strand breaks in peripheral blood mononuclear cells of individuals from high level natural radiation areas of Kerala coast in India

V Jain, PRV Kumar, PKM Koya, G Jaikrishan… - … Molecular Mechanisms of …, 2016 - Elsevier
The high level natural radiation area (HLNRA) of Kerala is a 55 km long and 0.5 km wide
strip in south west coast of India. The level of background radiation in this area varies from< …

The NAD+ precursor nicotinic acid improves genomic integrity in human peripheral blood mononuclear cells after X-irradiation

K Weidele, S Beneke, A Bürkle - DNA repair, 2017 - Elsevier
NAD+ is an essential cofactor for enzymes catalyzing redox-reactions as well as an electron
carrier in energy metabolism. Aside from this, NAD+ consuming enzymes like poly (ADP …

Radio‐adaptive response, individual radio‐sensitivity and correlation of base excision repair gene polymorphism (hOGG1, APE1, XRCC1, and LIGASE1) in human …

SM Toprani, B Das - Environmental and Molecular …, 2020 - Wiley Online Library
Radio‐adaptive response (RAR) is a biological mechanism, where cells primed with a low
dose exhibit reduced DNA damage with a high challenging dose. Single nucleotide …