Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence

D Richani, KR Dunning, JG Thompson… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

Identifying biomarkers for predicting successful embryo implantation: applying single to multi-OMICs to improve reproductive outcomes

P Hernández-Vargas, M Muñoz… - Human reproduction …, 2020 - academic.oup.com
BACKGROUND Successful embryo implantation is a complex process that requires the
coordination of a series of events, involving both the embryo and the maternal endometrium …

Integrated strategy for accurately screening biomarkers based on metabolomics coupled with network pharmacology

W Zhang, Y Chen, H Jiang, J Yang, Q Wang, Y Du… - Talanta, 2020 - Elsevier
Screening diagnostic biomarkers can be challenging due to the complexity of traditional
Chinese medicine (TCM) and ambiguous pharmacological mechanisms. In this study, we …

Follicular fluid: a powerful tool for the understanding and diagnosis of polycystic ovary syndrome

AT Brinca, AC Ramalhinho, Â Sousa, AH Oliani… - Biomedicines, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) represents one of the leading causes of anovulatory
infertility and affects 5% to 20% of women worldwide. Until today, both the subsequent …

[HTML][HTML] Why are multiple pregnancy rates and single embryo transfer rates so different globally, and what do we do about it?

GD Adamson, RJ Norman - Fertility and Sterility, 2020 - Elsevier
In the early years of in vitro fertilization, overall pregnancy rates were low, and it was
considered necessary to transfer more than one embryo to increase the chances of …

Capture and metabolomic analysis of the human endometrial epithelial organoid secretome

CA Simintiras, P Dhakal, C Ranjit… - Proceedings of the …, 2021 - National Acad Sciences
Suboptimal uterine fluid (UF) composition can lead to pregnancy loss and likely contributes
to offspring susceptibility to chronic adult-onset disorders. However, our understanding of …

Proteomics and metabolomics—Current and future perspectives in clinical andrology

MK Panner Selvam, R Finelli, A Agarwal… - Andrologia, 2021 - Wiley Online Library
Proteomics and metabolomics are emerging as promising tools to investigate the molecular
mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in …

Chemometric-guided approaches for profiling and authenticating botanical materials

EJ Abraham, JJ Kellogg - Frontiers in Nutrition, 2021 - frontiersin.org
Botanical supplements with broad traditional and medicinal uses represent an area of
growing importance for American health management; 25% of US adults use dietary …

Metabolomic biomarkers for detection, prognosis and identifying recurrence in endometrial cancer

K Njoku, CJJ Sutton, AD Whetton, EJ Crosbie - Metabolites, 2020 - mdpi.com
Metabolic reprogramming is increasingly recognised as one of the defining hallmarks of
tumorigenesis. There is compelling evidence to suggest that endometrial cancer develops …

Extracellular vesicles in the oviduct: progress, challenges and implications for the reproductive success

C Almiñana, S Bauersachs - Bioengineering, 2019 - mdpi.com
The oviduct is the anatomical part of the female reproductive tract where the early
reproductive events take place, from gamete transport, fertilization and early embryo …