A complex interplay of metabolic and immunological mechanisms underlies many diseases
that represent a substantial unmet medical need. There is an increasing appreciation of the …

Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

INTRODUCTION Cells respond to their environment, make decisions, build structures, and
coordinate tasks. Underlying these processes are computational operations performed by …

Synthetic gene networks have wide-ranging uses in reprogramming and rewiring
organisms. To date, there has not been a way to harness the vast potential of these networks …

The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …

Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …

Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …

Microbial engineering often requires fine control over protein expression—for example, to
connect genetic circuits,,,,,, or control flux through a metabolic pathway,,,,,. To circumvent the …

Genetic programs function to integrate environmental sensors, implement signal processing
algorithms and control expression dynamics. These programs consist of integrated genetic …

Computation underlies the organization of cells into higher-order structures, for example
during development or the spatial association of bacteria in a biofilm,,. Each cell performs a …