Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

[HTML][HTML] Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

TJ Clough, L Jiang, KL Wong, NJ Long - Nature communications, 2019 - nature.com
Gadolinium (III) complexes have been widely utilised as magnetic resonance imaging (MRI)
contrast agents for decades. In recent years however, concerns have developed about their …

Lanthanide probes for bioresponsive imaging

MC Heffern, LM Matosziuk, TJ Meade - Chemical reviews, 2014 - ACS Publications
The chemistry of the less familiar elements is a fascinating topic especially for the inorganic
minded. The lanthanides, or rare earths, comprise the 5d block of the periodic table and …

[图书][B] Handbook on the physics and chemistry of rare earths: including actinides

JCG Bunzli, VK Pecharsky - 2016 - books.google.com
Handbook on the Physics and Chemistry of Rare Earths: Including Actinides is a continuous
series of books covering all aspects of rare earth science, including chemistry, life sciences …

The use of the macrocyclic chelator DOTA in radiochemical separations

Z Baranyai, G Tircsó, F Rösch - European Journal of Inorganic …, 2020 - Wiley Online Library
Radiometals play an important role in the diagnosis of physiological processes in vivo by
means of imaging technologies, but also increasingly contribute to the treatment of diseases …

Rational Design of Gd-DOTA-Type Contrast Agents for Hepatobiliary Magnetic Resonance Imaging

W Xu, Y Lu, J Xu, H Li, R Lan, R Gao… - Journal of Medicinal …, 2023 - ACS Publications
The safety risks of gadolinium (Gd3+)-based contrast agents (GBCAs) arise from their
inevitable leakage of Gd3+, and the pursuit of more stable GBCAs for magnetic resonance …

[HTML][HTML] Lanthanide complexes with polyaminopolycarboxylates as prospective NMR/MRI diagnostic probes: peculiarities of molecular structure, dynamics and …

EN Zapolotsky, Y Qu, SP Babailov - Journal of Inclusion Phenomena and …, 2022 - Springer
The paramagnetic lanthanide complexes with polyaminopolycarboxylate (PAPC) ligands
attract considerable attention from the standpoint of potential applications thereof as …

Structural Variations in Carboxylated Bispidine Ligands: Influence of Positional Isomerism and Rigidity on the Conformation, Stability, Inertness and Relaxivity of their …

D Ndiaye, M Sy, W Thor… - … A European Journal, 2023 - Wiley Online Library
Abstract Mn2+ complexes of 2, 4‐pyridyl‐disubstituted bispidine ligands have emerged as
more biocompatible alternatives to Gd3+‐based MRI probes. They display relaxivities …

[HTML][HTML] Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications

L Dai, CM Jones, WTK Chan, TA Pham, X Ling… - Nature …, 2018 - nature.com
Despite established clinical utilisation, there is an increasing need for safer, more inert
gadolinium-based contrast agents, and for chelators that react rapidly with radiometals. Here …

Including and declaring structural fluctuations in the study of Lanthanide (III) coordination chemistry in solution

LG Nielsen, TJ Sørensen - Inorganic chemistry, 2019 - ACS Publications
The physicochemical properties of lanthanide (III) ions are directly linked to the structure of
the surrounding ligands. Rapid ligand exchange prohibits direct structure–property …