Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Cell death is an essential immunological apparatus of host defense, but dysregulation of
mutually inclusive cell deaths poses severe threats during microbial and parasitic infections …

Protein localisation and translocation between intracellular compartments underlie almost
all physiological processes. The hyperLOPIT proteomics platform combines mass …

Intervertebral disc degeneration (IDD) is the most critical pathological factor in the
development of low back pain. The maintenance of nucleus pulposus (NP) cell and …

Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are
present in almost all eukaryotic organisms, including humans. They are the key energy …

Mitochondrial function depends on the correct synthesis, transport, and assembly of proteins
and cofactors of the electron transport chain. The initial idea that the respiratory chain …

Perturbations of mitochondrial proteostasis have been associated with aging,
neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia …

The human mitochondrial genome (mtDNA) regulates its transcription products in
specialised and distinct ways as compared to nuclear transcription. Thanks to its mtDNA …

Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …

Although the large majority of mitochondrial proteins are nuclear encoded, for their correct
functioning mitochondria require the expression of 13 proteins, two rRNA, and 22 tRNA …