Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …

Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …

Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …

Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic
kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor …

Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …

Polycystin subunits can form hetero-and homotetrameric ion channels in the membranes of
various compartments of the cell. Homotetrameric polycystin channels are voltage-and …

Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant
polycystic kidneys. Background The proliferation of mural epithelial cells is a major cause of …

cAMP can be either mitogenic or anti-mitogenic, depending on the cell type. We
demonstrated previously that cAMP inhibited the proliferation of normal renal epithelial cells …