Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Iron is an essential element required by cells and has been described as a key player in
ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming …

Pseudo‐natural products (PNPs) combine natural product (NP) fragments in novel
arrangements not accessible by current biosynthesis pathways. As such they can be …

Autophagy is implicated in a wide range of (patho) physiological processes including
maintenance of cellular homeostasis, neurodegenerative disorders, aging and cancer. As …

Natural product structure and fragment-based compound development inspire pseudo-
natural product design through different combinations of a given natural product fragment …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

There is a great need for innovative new medicines to treat unmet medical needs. The
discovery and development of innovative new medicines is extremely difficult, costly, and …

Autophagy supports the fast growth of established tumors and promotes tumor resistance to
multiple treatments. Inhibition of autophagy is a promising strategy for tumor therapy …

PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin–proteasome system to
degrade a protein of interest for therapeutic benefit. Advances made in targeted protein …

Cancer stem cells (CSC) constitute a cell subpopulation in solid tumors that is responsible
for resistance to conventional chemotherapy, metastasis and cancer relapse. The natural …