BACKGROUND During the seminiferous epithelial cycle, restructuring takes places at the
Sertoli–Sertoli and Sertoli–germ cell interface to accommodate spermatogonia …

An increasing body of evidence suggests that several membrane receptors–in addition to
activating distinct signalling cascades–also engage in substantial crosstalk with each other …

The correct functioning of the nervous system depends on the exquisitely fine control of
neuronal excitability and synaptic plasticity, which relies on an intricate network of protein …

MicroRNAs (miRNAs) are short, conserved segments of non-coding RNA which play a
significant role in prostate cancer development and progression. To identify miRNAs …

The activation kinetics of MAPK Erk are critical for T cell development and activation. In
particular, sustained Erk signaling is required for T cell activation and effector functions, such …

Objective: Angiotensin II (Ang II)-induced endothelial dysfunction plays an important role in
the pathogenesis of cardiovascular diseases such as systemic hypertension, cardiac …

B cell antigen receptor (BCR) signaling is critical for B cell development and activation.
Using mass spectrometry, we identified a protein kinase D–interacting substrate of 220 kD …

Background: Neurotrophic signaling is an important factor in the survival of developing
neurons, and the expression of neurotrophic receptors correlates with prognosis in …

The mechanistic complexes of kinase D-interacting substrate of 220 kDa/ankyrin repeat-rich
membrane spanning (Kidins220/ARMS) bind and integrate a variety of cellular cues to …

Huntington's disease (HD) is an inherited progressive neurodegenerative disease
characterized by brain atrophy particularly in the striatum that produces motor impairment …