The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing …

Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …

The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal
survival and growth. Over the past decade, considerable evidence has accumulated from …

Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill
all mouse postmitotic sensory neurons expressing the sodium channel Nav1. 8. Mice …

Spinal long-term potentiation (LTP) at C-fiber synapses is hypothesized to underlie chronic
pain. However, a causal link between spinal LTP and chronic pain is still lacking. Here, we …

The increasing number of individuals with comorbidities poses an urgent need to improve
the management of patients with multiple co-existing diseases. Among these comorbidities …