Advances in sequencing technology

EY Chan - … Research/Fundamental and Molecular Mechanisms of …, 2005 - Elsevier
Faster sequencing methods will undoubtedly lead to faster single nucleotide polymorphism
(SNP) discovery. The Sanger method has served as the cornerstone for genome sequence …

Short cycle methods for sequencing polynucleotides

SN Lapidus, PR Buzby, T Harris - US Patent 7,169,560, 2007 - Google Patents
US7169560B2 - Short cycle methods for sequencing polynucleotides - Google Patents
US7169560B2 - Short cycle methods for sequencing polynucleotides - Google Patents …

Arrays of optical confinements and uses thereof

S Turner, J Korlach - US Patent 7,315,019, 2008 - Google Patents
The present invention relates to optical confinements, methods of preparing and methods of
using them for analyzing molecules and/or monitoring chemical reactions. The apparatus …

Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension

S Quake, I Braslavsky, B Hebert, E Kartalov - US Patent 7,297,518, 2007 - Google Patents
(54) METHODS AND APPARATUS FOR 4,962,037 A 10/1990 Jett et al. ANALYZING
POLYNUCLEOTIDE 4,971,903 A 11/1990 Hyman SEQUENCES BY ASYNCHRONOUS …

Method for sequencing nucleic acid molecules

J Korlach, WW Webb, M Levene, S Turner… - US Patent …, 2006 - Google Patents
The present invention is directed to a method of sequencing a target nucleic acid molecule
having a plurality of bases. In its principle, the temporal order of base additions during the …

Methods and apparatus for analyzing polynucleotide sequences

S Quake, W Volkmuth, M Unger - US Patent 6,911,345, 2005 - Google Patents
The present invention provides an apparatus for analyzing the sequences of
polynucleotides. The apparatus comprises (a) flow cell which has at least one …

Methods and apparatus for analyzing polynucleotide sequences

S Quake, M Unger - US Patent 6,818,395, 2004 - Google Patents
US6818395B1 - Methods and apparatus for analyzing polynucleotide sequences - Google
Patents US6818395B1 - Methods and apparatus for analyzing polynucleotide sequences …

Apparatus and methods for optical analysis of molecules

S Turner, J Korlach - US Patent 7,170,050, 2007 - Google Patents
The present invention relates to optical confinements, methods of preparing and methods of
using them for analyzing molecules and/or monitoring chemical reactions. The apparatus …

Method of determining the nucleotide sequence of oligonucleotides and DNA molecules

P Williams, TJ Taylor, DJB Williams, I Gould… - US Patent …, 2010 - Google Patents
The present invention relates to a novel method for analyzing nucleic acid sequences based
on real-time detection of DNA poly-merase-catalyzed incorporation of each of the four …

System and methods for nucleic acid sequencing of single molecules by polymerase synthesis

JGK Williams - US Patent 6,255,083, 2001 - Google Patents
US6255083B1 - System and methods for nucleic acid sequencing of single molecules by
polymerase synthesis - Google Patents US6255083B1 - System and methods for nucleic …