Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

Predicting the binding affinity of major histocompatibility complex I (MHC I) proteins and their
peptide ligands is important for vaccine design. We introduce an open-source package for …

T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …

Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

The use of peptides as therapeutics is experiencing renewed enthusiasm owing to
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use …

Receptor interactions with short linear peptide fragments (ligands) are at the base of many
biological signaling processes. Conserved and information-rich amino acid patterns …

Epstein-Barr virus (EBV) provides a useful model to study cellular immunity to a genetically
stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and …

HLA class I–binding predictions are widely used to identify candidate peptide targets of
human CD8+ T cell responses. Many such approaches focus exclusively on a limited range …

Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are
observed to dominate the response to the same antigenic epitope in multiple individuals …