Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

Macrophages, circulating in the blood or concatenated into different organs and tissues
constitute the first barrier against any disease. They are foremost controllers of both innate …

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by
chronic inflammation, demyelination, as well as axonal and neuronal loss in the central …

In addition to their early-recognized functions in host defense and the clearance of apoptotic
cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If …

Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

The immune microenvironment plays a critical role in regulating skin wound healing.
Macrophages, the main component of infiltrating inflammatory cells, play a pivotal role in …

Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central
nervous system (CNS). The early stage is characterized by relapses and the later stage, by …

Chronic wounds pose considerable public health challenges and burden. Wound healing is
known to require the participation of macrophages, but mechanisms remain unclear. The M1 …

Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …

Macrophages are key innate immune cells in the tumor microenvironment (TME) that
regulate primary tumor growth, vascularization, metastatic spread and tumor response to …