The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

The mitochondrial permeability transition (PT)–an abrupt increase permeability of the inner
membrane to solutes–is a causative event in ischemia–reperfusion injury of the heart, and …

Prolonged mitochondrial permeability transition pore (MPTP) opening results in
mitochondrial energetic dysfunction, organelle swelling, rupture, and typically a type of …

The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt
increase in the permeability of the inner mitochondrial membrane to low molecular weight …

The mitochondrial permeability transition pore is a high conductance channel whose
opening leads to an increase of mitochondrial inner membrane permeability to solutes with …

In addition to their normal physiological role in ATP production and metabolism,
mitochondria exhibit a dark side mediated by the opening of a non-specific pore in the inner …

VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …

Oxidative and nitrosative stress is increasingly associated with the pathology of
neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative …

Translocator protein of 18 kDa (TSPO) is a highly conserved, ubiquitous protein localized in
the outer mitochondrial membrane, where it is thought to play a key role in the mitochondrial …

A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …