Although lesion size is widely considered to be the most reliable predictor of outcome after
CNS injury, lesions of comparable size can produce vastly different magnitudes of functional …

Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …

The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Recent studies have demonstrated that bone marrow mesenchymal stem cells (BMSCs)
protect the injured neurons of spinal cord injury (SCI) from apoptosis while the underlying …

Epidermal growth factor (EGF) maintains intestinal stem cell (ISC) proliferation and is a key
component of organoid growth media yet is dispensable for intestinal homeostasis …

Background Limited progress in terms of an effective treatment for spinal cord injury (SCI)
emphasizes the urgent need for novel therapies. As a vital central nervous system …

Spontaneous remyelination occurs after spinal cord injury (SCI), but the extent of myelin
repair and identity of the cells responsible remain incompletely understood and contentious …

In the adult mammalian central nervous system (CNS), neurons typically fail to regenerate
their axons after injury. During development, by contrast, neurons extend axons effectively. A …

Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …

A phase 1 open-label, non-randomized clinical trial was conducted to determine feasibility
and safety of autologous human Schwann cell (ahSC) transplantation accompanied by …