The reception and integration of the plethora of signals a cell receives from its
microenvironment determines the cell's fate. CD44 functions as a receptor for hyaluronan …

Can an abundantly expressed molecule be a reliable marker for the cancer-initiating cells
(CICs; also known as cancer stem cells), which constitute the minority of cells within the …

CD44 is a broadly distributed cell surface protein thought to mediate cell attachment to
extracellular matrix components or specific cell surface ligands. We have created soluble …

The extracellular matrix glycosaminoglycan hyaluronan (HA) is an abundant component of
skin and mesenchymal tissues where it facilitates cell migration during wound healing …

Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in
the proper functioning of articular cartilage because it provides a hydrated gel structure (via …

Solid tumors are composed of mutually interacting cancer cells and tumor
microenvironment. Many environmental components, such as extracellular matrix (ECM) …

Publisher Summary CD44 is a ubiquitous multistructural and multifunctional cell surface
adhesion molecule involved in cell–cell and cell–matrix interactions. CD44s is a single …

Using a monoclonal antibody (MAbl. IASML) raised against s surface glycoprotein of the
metastsslzlng rat pancreatic carcinoma cell line BSp73ASML, cDNA clones have been …

When tissue loss disrupts normal architecture in higher vertebrate adult animals, the organ
fails to regenerate. Instead, repair proceeds as a fibroproliferative response that develops …

Proteoglycans are produced by most eukaryotic cells and are versatile components of
pericellular and extracellular matrices. They belong to many different protein families. Their …