The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

Because genetic alterations including mutations, overexpression, translocations, and
dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …

Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal
recessive early onset Parkinson's disease,. PINK1 has many unique features that enable it …

The RNA genome of SARS-CoV-2 contains a 5′ cap that facilitates the translation of viral
proteins, protection from exonucleases and evasion of the host immune response,,–. How …

Because mutations, overexpression, and dysregulation of protein kinases play essential
roles in the pathogenesis of many illnesses, this enzyme family has become one of the most …

Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …

Owing to the dysregulation of protein kinase activity in many diseases including cancer, the
protein kinase enzyme family has become one of the most important drug targets in the 21st …

Proteins often undergo large conformational changes when binding small molecules, but
atomic-level descriptions of such events have been elusive. Here, we report unguided …