Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells.
Owing to their ability to produce ATP through respiration, they became a driving force in …

Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby
triggering the type Ι interferon (IFN) response. Mitochondrial outer membrane …

Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A
(TFAM) into mitochondrial nucleoids that are of key importance in controlling the …

INTRODUCTION Mitochondria are endosymbiotic organelles that have their own genome
and perform many essential functions in eukaryotic cells, including ATP synthesis via …

Folates enable the activation and transfer of one-carbon units for the biosynthesis of purines,
thymidine and methionine,,. Antifolates are important immunosuppressive and anticancer …

DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …

Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial
nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial …

Mitochondria are the primary energy-generating system in most eukaryotic cells.
Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis …

Cytoplasmic RNA granules play a central role in mRNA metabolism, but the importance of
mitochondrial RNA granules remains relatively unexplored. We characterized their …