Cu (I)-catalyzed click chemistry in glycoscience and their diverse applications

AK Agrahari, P Bose, MK Jaiswal, S Rajkhowa… - Chemical …, 2021 - ACS Publications
Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Cu-catalyzed click reaction in carbohydrate chemistry

VK Tiwari, BB Mishra, KB Mishra, N Mishra… - Chemical …, 2016 - ACS Publications
Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

CuAAC-ensembled 1, 2, 3-triazole-linked isosteres as pharmacophores in drug discovery

A Rani, G Singh, A Singh, U Maqbool, G Kaur… - RSC advances, 2020 - pubs.rsc.org
The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …

“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

W Tang, ML Becker - Chemical Society Reviews, 2014 - pubs.rsc.org
Peptides that comprise the functional subunits of proteins have been conjugated to versatile
materials (biomolecules, polymers, surfaces and nanoparticles) in an effort to modulate cell …

Rationally designed peptides and peptidomimetics as inhibitors of amyloid-β (Aβ) aggregation: Potential therapeutics of Alzheimer's disease

D Goyal, S Shuaib, S Mann, B Goyal - ACS combinatorial science, 2017 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …

Glycotherapy: new advances inspire a reemergence of glycans in medicine

JE Hudak, CR Bertozzi - Chemistry & biology, 2014 - cell.com
The beginning of the 20 th century marked the dawn of modern medicine with glycan-based
therapies at the forefront. However, glycans quickly became overshadowed as DNA-and …

Multicomponent Syntheses based upon Copper‐Catalyzed Alkyne‐Azide Cycloaddition

S Hassan, TJJ Mueller - Advanced Synthesis & Catalysis, 2015 - Wiley Online Library
The copper‐catalyzed alkyne‐azide cycloaddition (CuAAC) is a highly versatile,
regioselective synthesis of 1, 4‐disubstituted 1, 2, 3‐triazoles under mild reaction conditions …

Palladium mediated rapid deprotection of N-terminal cysteine under native chemical ligation conditions for the efficient preparation of synthetically challenging …

M Jbara, SK Maity, M Seenaiah… - Journal of the American …, 2016 - ACS Publications
Facilitating the process of chemical protein synthesis is an important goal in order to enable
the efficient preparation of large and novel protein analogues. Native chemical ligation …

Synthesis of glycopeptides and glycopeptide conjugates

W Doelman, SI van Kasteren - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
Protein glycosylation is a key post-translational modification important to many facets of
biology. Glycosylation can have critical effects on protein conformation, uptake and …

Protecting‐group‐free one‐pot synthesis of glycoconjugates directly from reducing sugars

D Lim, MA Brimble, R Kowalczyk… - Angewandte …, 2014 - Wiley Online Library
The conversion of sugars into glycomimetics typically involves multiple protecting‐group
manipulations. The development of methodology allowing the direct aqueous conversion of …