Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading
cause of cancer-related death for American men due to a subset of patients progressing to …

Covering: 2011 to 2021 Trifluoromethyl (CF3)-modified natural products have attracted
increasing interest due to their magical effect in binding affinity and/or drug metabolism and …

Peptidyl-proline isomerases (PPIases) are a chaperone superfamily comprising the FK506-
binding proteins (FKBPs), cyclophilins, and parvulins. PPIases catalyze the cis/trans …

Src homology 2 (SH2) domains are 100 amino acid modular units, which recognize and
bind to tyrosyl-phosphorylated peptide sequences on their target proteins, and thereby …

A catalytic regime for the direct phosphatation of simple, non‐polarized alkenes has been
devised that is based on using ordinary, non‐activated phosphoric acid diesters as the …

Abstract Src homology 2 (SH2) domains play a central role in signal transduction. Although
many SH2 domains have been validated as drug targets, their structural similarity makes …

Enzyme-instructed self-assembly (EISA) and hydrogelation is a versatile approach for
generating soft materials. Most of the substrates for alkaline phosphatase catalysed EISA …

The transcription factor STAT5b is a target for tumour therapy. We recently reported catechol
bisphosphate and derivatives such as Stafib-1 as the first selective inhibitors of the STAT5b …

The breast cancer type 1 susceptibility protein (BRCA1) and its partner–the BRCA1-
associated RING domain protein 1 (BARD1)–are key players in a plethora of fundamental …