Sepsis is a persistent systemic inflammatory condition involving multiple organ failures
resulting from a dysregulated immune response to infection, and one of the hallmarks of …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Higher organisms rely on a closed cardiovascular circulatory system with blood vessels
supplying vital nutrients and oxygen to distant tissues. Not surprisingly, vascular pathologies …

The endothelium acts as the barrier that prevents circulating lipids such as lipoproteins and
fatty acids into the arterial wall; it also regulates normal functioning in the circulatory system …

In contrast to the general belief, endothelial cell (EC) metabolism has recently been
identified as a driver rather than a bystander effect of angiogenesis in health and disease …

Angiogenesis has traditionally been viewed from the perspective of how endothelial cells
(ECs) coordinate migration and proliferation in response to growth factor activation to form …

Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis.
Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and …

Mitochondria are perhaps the most sophisticated and dynamic responsive sensing systems
in eukaryotic cells. The role of mitochondria goes beyond their capacity to create molecular …

Endothelial cells (ECs) require glycolysis for proliferation and migration during
angiogenesis; however, the necessity for the mitochondrial respiratory chain during …

Currently, a marked number of clinical trials on cancer treatment have revealed the success
of immunomodulatory therapies based on immune checkpoint inhibitors that activate tumor …