Vaspin (serpinA12) in obesity, insulin resistance, and inflammation

JT Heiker - Journal of Peptide Science, 2014 - Wiley Online Library
While genome‐wide association studies as well as candidate gene studies have revealed a
great deal of insight into the contribution of genetics to obesity development and …

[HTML][HTML] Angiotensin II type 1 receptor antagonists in animal models of vascular, cardiac, metabolic and renal disease

MC Michel, HR Brunner, C Foster, Y Huo - Pharmacology & therapeutics, 2016 - Elsevier
We have reviewed the effects of angiotensin II type 1 receptor antagonists (ARBs) in various
animal models of hypertension, atherosclerosis, cardiac function, hypertrophy and fibrosis …

Methylglyoxal-induced endothelial cell loss and inflammation contribute to the development of diabetic cardiomyopathy

B Vulesevic, B McNeill, F Giacco, K Maeda… - Diabetes, 2016 - Am Diabetes Assoc
The mechanisms for the development of diabetic cardiomyopathy remain largely unknown.
Methylglyoxal (MG) can accumulate and promote inflammation and vascular damage in …

Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure

S Ogawa, K Nakayama, M Nakayama, T Mori… - …, 2010 - Am Heart Assoc
We test whether plasma level of methylglyoxal (MG) is an independent risk factor predicting
the progression of diabetic macroangiopathy or microangiopathy in type 2 diabetic patients …

Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway

P Chu, G Han, A Ahsan, Z Sun, S Liu, Z Zhang… - Vascular …, 2017 - Elsevier
Methylglyoxal (MGO), an active metabolite of glucose, can cause cellular injury which has
an affinity for the progression of diabetes-associated atherosclerosis. Phosphocreatine (PCr) …

Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells

H Yamawaki, K Saito, M Okada… - American Journal of …, 2008 - journals.physiology.org
Methylglyoxal (MGO) is a reactive metabolite of glucose. Since the plasma concentration of
MGO is increased in diabetic patients, MGO is implicated in diabetes-associated vascular …

Vaspin prevents methylglyoxal‐induced apoptosis in human vascular endothelial cells by inhibiting reactive oxygen species generation

S Phalitakul, M Okada, Y Hara… - Acta Physiologica, 2013 - Wiley Online Library
Aim Vaspin (visceral adipose tissue‐derived serine protease inhibitor) is a novel
adipocytokine found in visceral white adipose tissues of obese type 2 diabetic rats. We have …

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells

JL Figarola, J Singhal, S Rahbar, S Awasthi… - Apoptosis, 2014 - Springer
Methylglyoxal (MGO) is a highly reactive dicarbonyl compound known to induce cellular
injury and cytoxicity, including apoptosis in vascular cells. Vascular endothelial cell …

Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells

JD Braun, DO Pastene, A Breedijk, A Rodriguez… - Scientific reports, 2019 - nature.com
Although methylglyoxal (MGO) has emerged as key mediator of diabetic microvascular
complications, the influence of MGO on the vascular transcriptome has not thoroughly been …

Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury

AA Fouad, HA Qureshi, AI Al-Sultan, MT Yacoubi… - Pharmacology, 2010 - karger.com
We investigated the protective effect of telmisartan, an angiotensin II receptor antagonist,
against ischemia/reperfusion renal injury in rats. Bilateral ischemia was induced by …