The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
Regulating tumor suppressor genes: post-translational modifications
L Chen, S Liu, Y Tao - Signal transduction and targeted therapy, 2020 - nature.com
Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
Mechanisms of PTEN loss in cancer: It's all about diversity
V Álvarez-Garcia, Y Tawil, HM Wise… - Seminars in cancer biology, 2019 - Elsevier
PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
PTEN function: the long and the short of it
BD Hopkins, C Hodakoski, D Barrows… - Trends in biochemical …, 2014 - cell.com
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that
is frequently altered in cancer. PTEN has phosphatase-dependent and-independent roles …
is frequently altered in cancer. PTEN has phosphatase-dependent and-independent roles …
PTEN tumor suppressor network in PI3K-Akt pathway control
MM Georgescu - Genes & cancer, 2010 - journals.sagepub.com
The PI3K-Akt pathway is a major survival pathway activated in cancer. Efforts to develop
targeted therapies have not been fully successful, mainly because of extensive internal …
targeted therapies have not been fully successful, mainly because of extensive internal …
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal
physiology and in the pathogenesis of many diseases. Chemotactic cells display motility …
physiology and in the pathogenesis of many diseases. Chemotactic cells display motility …
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases
Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …
Therapeutic targeting of cancers with loss of PTEN function
LM Dillon, TW Miller - Current drug targets, 2014 - ingentaconnect.com
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is one of the most
frequently disrupted tumor suppressors in cancer. The lipid phosphatase activity of PTEN …
frequently disrupted tumor suppressors in cancer. The lipid phosphatase activity of PTEN …
Intrinsically disordered proteins play diverse roles in cell signaling
Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …