[HTML][HTML] The blood-brain barrier studied in vitro across species
The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (BECs)
supported by pericytes and astrocytes. The BBB maintains homeostasis and protects the …
supported by pericytes and astrocytes. The BBB maintains homeostasis and protects the …
TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation
H Ahmadighadykolaei, JA Lambert… - Pharmaceutical …, 2023 - Springer
Objective The blood–brain barrier (BBB) plays a critical role in central nervous system
homeostasis, and the integrity of BBB is disrupted in many neurodegenerative diseases …
homeostasis, and the integrity of BBB is disrupted in many neurodegenerative diseases …
[HTML][HTML] Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells
Background In severe acute pancreatitis (AP) the CNS is affected manifesting in
neurological symptoms. Earlier research from our laboratory showed blood–brain barrier …
neurological symptoms. Earlier research from our laboratory showed blood–brain barrier …
In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells
The BBB is a protective entity that prevents external substances from reaching the CNS but it
also hinders the delivery of drugs into the brain when they are needed. The main objective …
also hinders the delivery of drugs into the brain when they are needed. The main objective …
[HTML][HTML] Interspecies brain pbpk modeling platform to predict passive transport through the blood–brain barrier and assess target site disposition
The high failure rate of central nervous system (CNS) drugs is partly associated with an
insufficient understanding of target site exposure. Blood–brain barrier (BBB) permeability …
insufficient understanding of target site exposure. Blood–brain barrier (BBB) permeability …
Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability
MA García, D Contreras, PM González - Pharmaceutical Research, 2020 - Springer
Purpose MDCK cells are commonly used to assess drug permeability, but the existence of
various strains merits a comparative functional study. Since metformin absorption is largely …
various strains merits a comparative functional study. Since metformin absorption is largely …