Cancer cellular heterogeneity and therapy resistance arise substantially from metabolic and
transcriptional adaptations, but how these are interconnected is poorly understood. Here, we …

Endogenous formaldehyde (FA) is produced in the human body via various mechanisms to
preserve healthy energy metabolism and safeguard the organism. However, endogenous …

Formate is a major reactive carbon species in one-carbon metabolism, where it serves as an
endogenous precursor for amino acid and nucleic acid biosynthesis and a cellular source of …

Tumor microenvironment (TME) of solid tumors including breast cancer is complex and
contains a distinct cytokine pattern including TNF-α, which determines the progression and …

We have identified a set of Japanese children with hypoplastic anemia caused by combined
defects in aldehyde degrading enzymes ADH5 and ALDH2. Their clinical characteristics …

Genes mutated in monogenic neurodevelopmental disorders are broadly expressed. This
observation supports the concept that monogenic neurodevelopmental disorders are …

Formaldehyde is a highly reactive organic compound. Humans can be exposed to
exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a …

Rare inherited diseases caused by mutations in the copper transporters SLC31A1 (CTR1) or
ATP7A induce copper deficiency in the brain and throughout the body, causing seizures and …

Acute myeloid leukaemia (AML) is a haematopoietic malignancy comprising different
genetic subtypes with a common hallmark of differentiation arrest. In abnormal …

Cancer cellular heterogeneity and therapy resistance arise substantially from metabolic and
transcriptional adaptations, but how these are interconnected is poorly understood. Here, we …