The success of inactivated and live-attenuated vaccines has enhanced livestock
productivity, promoted food security, and attenuated the morbidity and mortality of several …

Influenza A viruses cause acute respiratory infections in swine that result in significant
economic losses for global pig production. Currently, three different subtypes of influenza A …

Recombinant nucleic acids are considered as promising next-generation vaccines. These
vaccines express the native antigen upon delivery into tissue, thus mimicking live attenuated …

Influenza A virus in swine (IAV-S) is one of the most important infectious disease agents of
swine in North America. In addition to the economic burden of IAV-S to the swine industry …

Single-stranded RNA viruses of both positive and negative polarity have been used as
vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus …

A transmission experiment involving 5-week-old specific-pathogen-free (SPF) piglets, with
(MDA+) or without maternally-derived antibodies (MDA−), was carried out to evaluate the …

Antigenic drift of seasonal influenza viruses and the occasional introduction of influenza
viruses of novel subtypes into the human population complicate the timely production of …

The alphavirus replicon technology has been utilized for many years to develop vaccines for
both veterinary and human applications. Many developments have been made to the …

A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine
influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different …

Swine influenza is an acute respiratory disease of pigs caused by influenza A virus (IAV)
and characterized by fever followed by lethargy, anorexia, and serous nasal discharge. The …