Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the
most common monogenic diseases worldwide. Several clinical forms of α-thalassaemia and …

Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike
patients with beta (β)-thalassemia major, do not require regular transfusion therapy for …

Recent molecular studies of fetal hemoglobin (HbF) regulation have reinvigorated the field
and shown promise for the development of clinical HbF inducers to be used in patients with …

Our understanding of the molecular and pathophysiological mechanisms underlying the
disease process in patients with β thalassaemia intermedia (TI) has substantially increased …

Our understanding of the molecular and pathophysiological mechanisms underlying the
disease process in patients with β-thalassemia intermedia has substantially increased over …

Extra‐medullary haematopoiesis (EMH) occurs in many haematological disorders and is
secondary to insufficient bone marrow function or ineffective erythropoiesis. It usually …

Abstract β-Thalassemia intermedia is a clinical condition of intermediate gravity between β-
thalassemia minor, the asymptomatic carrier, and β-thalassemia major, the transfusion …

Beta-thalassemia intermedia (β-TI) is a genetic variant of beta-thalassemias with a clinical
disorder whose severity falls between thalassemia minor and thalassemia major. Different …

Patients with non-transfusion-dependent thalassemia (NTDT) experience many clinical
complications despite their independence from frequent transfusions. Morbidities in NTDT …

Non-transfusion-dependent thalassemia (NTDT) has been considered less severe than its
transfusion-dependent variants. The most common forms of NTDT include β-thalassemia …