Advances in computational methods to discover new NS2B-NS3 inhibitors useful against dengue and Zika viruses
IJ dos Santos Nascimento… - Current Topics in …, 2022 - ingentaconnect.com
The Flaviviridae virus family consists of the genera Hepacivirus, Pestivirus, and Flavivirus,
with approximately 70 viral types that use arthropods as vectors. Among these diseases …
with approximately 70 viral types that use arthropods as vectors. Among these diseases …
Unveiling the antiviral potential of plant compounds from the Meliaceae family against the Zika virus through QSAR modeling and MD simulation analysis
D Shukla, AM Alanazi, SP Panda… - Journal of …, 2023 - Taylor & Francis
Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes, causing neurological disorders
and congenital malformations. RNA-dependent RNA polymerase (RdRp) is one of its …
and congenital malformations. RNA-dependent RNA polymerase (RdRp) is one of its …
Discovery of Hybrid Thiouracil–Coumarin Conjugates as Potential Novel Anti-SARS-CoV-2 Agents Targeting the Virus's Polymerase “RdRp” as a Confirmed …
D Vishwanath, A Shete-Aich, MB Honnegowda… - ACS …, 2023 - ACS Publications
The coronavirus (COVID-19) pandemic, along with its various strains, has emerged as a
global health crisis that has severely affected humankind and posed a great challenge to the …
global health crisis that has severely affected humankind and posed a great challenge to the …
Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C–H Dibenzothiophenation and Negishi Coupling
C Yang, LP Slavetinska, M Fleuti… - Journal of the …, 2022 - ACS Publications
A new approach for synthesizing polycyclic heterofused 7-deazapurine heterocycles and the
corresponding nucleosides was developed based on C–H functionalization of diverse …
corresponding nucleosides was developed based on C–H functionalization of diverse …
Recent advances in the study of zika virus structure, drug targets, and inhibitors
Y Feng - Frontiers in Pharmacology, 2024 - frontiersin.org
Zika Virus (ZIKV) is a positive-strand RNA virus that can lead to Guillain-Barré syndrome or
encephalitis in some individuals and hence presents a serious public health risk. Since the …
encephalitis in some individuals and hence presents a serious public health risk. Since the …
Natural compounds as non-nucleoside inhibitors of Zika virus polymerase through integration of in silico and in vitro approaches
Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological
consequences for infected infants and adults, there are still no approved drugs to treat ZIKV …
consequences for infected infants and adults, there are still no approved drugs to treat ZIKV …
Discovery of new Zika protease and polymerase inhibitors through the open science collaboration Project OpenZika
M Mottin, BK de Paula Sousa… - Journal of chemical …, 2022 - ACS Publications
The Zika virus (ZIKV) is a neurotropic arbovirus considered a global threat to public health.
Although there have been several efforts in drug discovery projects for ZIKV in recent years …
Although there have been several efforts in drug discovery projects for ZIKV in recent years …
Fragment-based design of α-cyanoacrylates and α-cyanoacrylamides targeting Dengue and Zika NS2B/NS3 proteases
GG Vilela, WF dos Santos Silva… - New Journal of …, 2022 - pubs.rsc.org
Viruses belonging to the Flaviviridae family account for millions of cases of infections
worldwide, mainly Dengue (DENV) and Zika (ZIKV) viruses. Both mosquito-borne …
worldwide, mainly Dengue (DENV) and Zika (ZIKV) viruses. Both mosquito-borne …
Discovery of ZFD-10 of a pyridazino [4, 5-b] indol-4 (5H)-one derivative as an anti-ZIKV agent and a ZIKV NS5 RdRp inhibitor
GF Zhou, W Qian, F Li, RH Yang, N Wang, CB Zheng… - Antiviral Research, 2023 - Elsevier
Zika virus (ZIKV) infection is associated with the birth defect microcephaly and Guillain–
Barré syndrome in adults. There is no approved vaccine or specific antiviral agent against …
Barré syndrome in adults. There is no approved vaccine or specific antiviral agent against …
The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase
S Boonyasuppayakorn, T Saelee, TNT Huynh… - Scientific Reports, 2023 - nature.com
Dengue and Zika viruses are mosquito-borne flaviviruses burdening millions every year with
hemorrhagic fever and neurological symptoms. Baicalein was previously reported as a …
hemorrhagic fever and neurological symptoms. Baicalein was previously reported as a …