Advances in computational methods to discover new NS2B-NS3 inhibitors useful against dengue and Zika viruses

IJ dos Santos Nascimento… - Current Topics in …, 2022 - ingentaconnect.com
The Flaviviridae virus family consists of the genera Hepacivirus, Pestivirus, and Flavivirus,
with approximately 70 viral types that use arthropods as vectors. Among these diseases …

Unveiling the antiviral potential of plant compounds from the Meliaceae family against the Zika virus through QSAR modeling and MD simulation analysis

D Shukla, AM Alanazi, SP Panda… - Journal of …, 2023 - Taylor & Francis
Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes, causing neurological disorders
and congenital malformations. RNA-dependent RNA polymerase (RdRp) is one of its …

Discovery of Hybrid Thiouracil–Coumarin Conjugates as Potential Novel Anti-SARS-CoV-2 Agents Targeting the Virus's Polymerase “RdRp” as a Confirmed …

D Vishwanath, A Shete-Aich, MB Honnegowda… - ACS …, 2023 - ACS Publications
The coronavirus (COVID-19) pandemic, along with its various strains, has emerged as a
global health crisis that has severely affected humankind and posed a great challenge to the …

Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C–H Dibenzothiophenation and Negishi Coupling

C Yang, LP Slavetinska, M Fleuti… - Journal of the …, 2022 - ACS Publications
A new approach for synthesizing polycyclic heterofused 7-deazapurine heterocycles and the
corresponding nucleosides was developed based on C–H functionalization of diverse …

Recent advances in the study of zika virus structure, drug targets, and inhibitors

Y Feng - Frontiers in Pharmacology, 2024 - frontiersin.org
Zika Virus (ZIKV) is a positive-strand RNA virus that can lead to Guillain-Barré syndrome or
encephalitis in some individuals and hence presents a serious public health risk. Since the …

Natural compounds as non-nucleoside inhibitors of Zika virus polymerase through integration of in silico and in vitro approaches

PRPS Ramos, M Mottin, CS Lima, LR Assis… - Pharmaceuticals, 2022 - mdpi.com
Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological
consequences for infected infants and adults, there are still no approved drugs to treat ZIKV …

Discovery of new Zika protease and polymerase inhibitors through the open science collaboration Project OpenZika

M Mottin, BK de Paula Sousa… - Journal of chemical …, 2022 - ACS Publications
The Zika virus (ZIKV) is a neurotropic arbovirus considered a global threat to public health.
Although there have been several efforts in drug discovery projects for ZIKV in recent years …

Fragment-based design of α-cyanoacrylates and α-cyanoacrylamides targeting Dengue and Zika NS2B/NS3 proteases

GG Vilela, WF dos Santos Silva… - New Journal of …, 2022 - pubs.rsc.org
Viruses belonging to the Flaviviridae family account for millions of cases of infections
worldwide, mainly Dengue (DENV) and Zika (ZIKV) viruses. Both mosquito-borne …

Discovery of ZFD-10 of a pyridazino [4, 5-b] indol-4 (5H)-one derivative as an anti-ZIKV agent and a ZIKV NS5 RdRp inhibitor

GF Zhou, W Qian, F Li, RH Yang, N Wang, CB Zheng… - Antiviral Research, 2023 - Elsevier
Zika virus (ZIKV) infection is associated with the birth defect microcephaly and Guillain–
Barré syndrome in adults. There is no approved vaccine or specific antiviral agent against …

The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase

S Boonyasuppayakorn, T Saelee, TNT Huynh… - Scientific Reports, 2023 - nature.com
Dengue and Zika viruses are mosquito-borne flaviviruses burdening millions every year with
hemorrhagic fever and neurological symptoms. Baicalein was previously reported as a …