[HTML][HTML] Intrinsically disordered proteins: an overview
R Trivedi, HA Nagarajaram - International journal of molecular sciences, 2022 - mdpi.com
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …
structure under physiological conditions; instead, they adopt multiple interconverting …
Intrinsically disordered proteins: critical components of the wetware
P Kulkarni, S Bhattacharya, S Achuthan… - Chemical …, 2022 - ACS Publications
Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since
their discovery, there are several aspects that remain unexplored and, hence, poorly …
their discovery, there are several aspects that remain unexplored and, hence, poorly …
[HTML][HTML] Liquid–liquid phase separation as an organizing principle of intracellular space: Overview of the evolution of the cell compartmentalization concept
IA Antifeeva, AV Fonin, AS Fefilova… - Cellular and Molecular …, 2022 - Springer
At the turn of the twenty-first century, fundamental changes took place in the understanding
of the structure and function of proteins and then in the appreciation of the intracellular …
of the structure and function of proteins and then in the appreciation of the intracellular …
Tutorial: a guide for the selection of fast and accurate computational tools for the prediction of intrinsic disorder in proteins
L Kurgan, G Hu, K Wang, S Ghadermarzi, B Zhao… - Nature …, 2023 - nature.com
Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using
computational predictions from primary structures, complements secondary and tertiary …
computational predictions from primary structures, complements secondary and tertiary …
DeepDISOBind: accurate prediction of RNA-, DNA-and protein-binding intrinsically disordered residues with deep multi-task learning
F Zhang, B Zhao, W Shi, M Li… - Briefings in …, 2022 - academic.oup.com
Proteins with intrinsically disordered regions (IDRs) are common among eukaryotes. Many
IDRs interact with nucleic acids and proteins. Annotation of these interactions is supported …
IDRs interact with nucleic acids and proteins. Annotation of these interactions is supported …
A systematic approach to the discovery of protein–protein interaction stabilizers
DN Kenanova, EJ Visser, JM Virta, E Sijbesma… - ACS central …, 2023 - ACS Publications
Dysregulation of protein–protein interactions (PPIs) commonly leads to disease. PPI
stabilization has only recently been systematically explored for drug discovery despite being …
stabilization has only recently been systematically explored for drug discovery despite being …
On the specificity of protein–protein interactions in the context of disorder
K Teilum, JG Olsen, BB Kragelund - Biochemical Journal, 2021 - portlandpress.com
With the increased focus on intrinsically disordered proteins (IDPs) and their large
interactomes, the question about their specificity—or more so on their multispecificity—arise …
interactomes, the question about their specificity—or more so on their multispecificity—arise …
Intrinsically disordered proteins: the dark horse of the dark proteome
P Kulkarni, VN Uversky - Proteomics, 2018 - Wiley Online Library
A good portion of the 'protein universe'embodies the 'dark proteome'. The latter comprises
proteins not amenable to experimental structure determination by existing means and …
proteins not amenable to experimental structure determination by existing means and …
[HTML][HTML] Protein aggregation landscape in neurodegenerative diseases: Clinical relevance and future applications
N Candelise, S Scaricamazza, I Salvatori… - International journal of …, 2021 - mdpi.com
Intrinsic disorder is a natural feature of polypeptide chains, resulting in the lack of a defined
three-dimensional structure. Conformational changes in intrinsically disordered regions of a …
three-dimensional structure. Conformational changes in intrinsically disordered regions of a …
[HTML][HTML] Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson's disease patients
E Zago, A Dal Molin, GM Dimitri, L Xumerle… - Scientific reports, 2022 - nature.com
Advanced age represents one of the major risk factors for Parkinson's Disease. Recent
biomedical studies posit a role for microRNAs, also known to be remodelled during ageing …
biomedical studies posit a role for microRNAs, also known to be remodelled during ageing …