Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: a systematic review

I Pacchiarotti, J Tiihonen, GD Kotzalidis… - European …, 2019 - Elsevier
Abstract Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance
in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available …

Atypical antipsychotic drugs in dual disorders: current evidence for clinical practice

G Martinotti, S Chiappini, A Mosca… - Current …, 2022 - ingentaconnect.com
Background: Concurrent disorder or dual diagnosis refers to a combination of substance use
disorders and mental disorders that occur in the same patient simultaneously. These …

Maintenance treatment with long-acting injectable antipsychotics for people with nonaffective psychoses: a network meta-analysis

G Ostuzzi, F Bertolini, C Del Giovane… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: This study compared relapse prevention and acceptability of long-acting
injectable (LAI) antipsychotics in the maintenance treatment of adults with nonaffective …

[HTML][HTML] Dopamine receptor partial agonists: Do they differ in their clinical efficacy?

P Mohr, J Masopust, M Kopeček - Frontiers in Psychiatry, 2022 - frontiersin.org
Dopamine receptor partial agonists (DRPAs; aripiprazole, brexpiprazole, and cariprazine)
constitute a novel class of antipsychotics. Although they share a similar mechanism of …

Long-acting antipsychotics in the treatment of schizophrenia: opportunities and challenges

PM Haddad, CU Correll - Expert Opinion on Pharmacotherapy, 2023 - Taylor & Francis
Introduction Maintenance antipsychotic treatment improves multiple outcomes in people with
schizophrenia. These benefits are challenged by medication nonadherence, which is a …

Long-acting injectable antipsychotic treatment in schizophrenia and co-occurring substance use disorders: a systematic review

AS Coles, D Knezevic, TP George, CU Correll… - Frontiers in …, 2021 - frontiersin.org
Objectives: Co-occurring substance use disorders (SUDs) among individuals with
schizophrenia are a prevalent and complex psychiatric comorbidity, which is associated with …

Brexpiprazole in patients with schizophrenia with or without substance use disorder: an observational study

G Lombardozzi, G Trovini, E Amici… - Frontiers in …, 2023 - frontiersin.org
Background Partial dopamine D2 receptor agonists are used for psychotic symptoms in
adults with schizophrenia spectrum disorders. Recently, interest surged for partial dopamine …

High rate of discontinuation during long-acting injectable antipsychotic treatment in patients with psychotic disorders

AM Auxilia, M Buoli, A Caldiroli, GS Carnevali… - Biomedicines, 2023 - mdpi.com
Treatment discontinuation is a major challenge in routine clinical settings. Despite poor
adherence to antipsychotic medication, long acting injectable (LAI) formulations are an …

Long‐acting antipsychotic medication as first‐line treatment of first‐episode psychosis with comorbid substance use disorder

A Abdel‐Baki, D Thibault, S Medrano… - Early Intervention in …, 2020 - Wiley Online Library
Aim Substance use disorder (SUD) is highly prevalent among patients with first‐episode
psychosis (FEP) and associated with poor adherence and worst treatment outcomes …

The role of the D3 dopamine receptor and its partial agonist cariprazine in patients with schizophrenia and substance use disorder

H Grunze - Expert Opinion on Pharmacotherapy, 2023 - Taylor & Francis
Introduction Comorbidity of substance use disorder (SUD) with schizophrenia, referred to as
dual disorder (DD), significantly increases morbidity and mortality compared to …