[HTML][HTML] Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines
WG Dos Santos - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) continues to challenge most scientists in the
search of an effective way to either prevent infection or to avoid spreading of the disease. As …
search of an effective way to either prevent infection or to avoid spreading of the disease. As …
Immunoinformatics and vaccine development: an overview
AN Oli, WO Obialor, MO Ifeanyichukwu… - ImmunoTargets and …, 2020 - Taylor & Francis
The use of vaccines have resulted in a remarkable improvement in global health. It has
saved several lives, reduced treatment costs and raised the quality of animal and human …
saved several lives, reduced treatment costs and raised the quality of animal and human …
A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection
DG Augusto, LD Murdolo, DSM Chatzileontiadou… - Nature, 2023 - nature.com
Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2
remain asymptomatic,,–. Although most global efforts have focused on severe illness in …
remain asymptomatic,,–. Although most global efforts have focused on severe illness in …
[HTML][HTML] COVID-19 infection: the perspectives on immune responses
More than 100 years since the outbreak of the 1918 influenza pandemic, we now seem to
face another pandemic. The outbreak of the new coronavirus (SARS-CoV-2) infection is …
face another pandemic. The outbreak of the new coronavirus (SARS-CoV-2) infection is …
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations
FF González-Galarza, LYC Takeshita… - Nucleic acids …, 2015 - academic.oup.com
It has been 12 years since the Allele Frequency Net Database (AFND; http://www.
allelefrequencies. net) was first launched, providing the scientific community with an online …
allelefrequencies. net) was first launched, providing the scientific community with an online …
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
C Tian, BS Hromatka, AK Kiefer, N Eriksson… - Nature …, 2017 - nature.com
Infectious diseases have a profound impact on our health and many studies suggest that
host genetics play a major role in the pathogenesis of most of them. We perform 23 genome …
host genetics play a major role in the pathogenesis of most of them. We perform 23 genome …
HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis
The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …
Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19
Background Understanding how HLA polymorphisms may affect both susceptibility, course
and severity of Covid-19 infection could help both at the clinical level to identify individuals …
and severity of Covid-19 infection could help both at the clinical level to identify individuals …
[HTML][HTML] Genetic gateways to COVID‐19 infection: implications for risk, severity, and outcomes
The dynamics, such as transmission, spatial epidemiology, and clinical course of
Coronavirus Disease‐2019 (COVID‐19) have emerged as the most intriguing features and …
Coronavirus Disease‐2019 (COVID‐19) have emerged as the most intriguing features and …
Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients
I Iturrieta-Zuazo, CG Rita, A García-Soidán… - Clinical …, 2020 - Elsevier
Abstract Human Leukocyte Antigen (HLA) includes a large set of genes with important
actions in immune response against viral infection. Numerous studies have revealed the …
actions in immune response against viral infection. Numerous studies have revealed the …