Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

Wilms' tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors
morphologically resemble embryonic kidneys with a disrupted architecture and are …

A better molecular understanding of gastrointestinal cancers arising either from the stomach,
the pancreas, the intestine, or the liver has led to the identification of a variety of potential …

The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that
could replenish functional homeostasis similarly to, eg, skin or the hematopoietic system …

Worldwide, over 1300 pediatric kidney transplantations are performed every year. Since the
first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive …

Lineage tracing is a powerful tool to track cells in vivo and provides enhanced spatial,
temporal, and kinetic resolution of the mechanisms that underlie tissue renewal and repair …

The capacity for tumor cells to metastasize efficiently is directly linked to their ability to
colonize secondary sites. Here we identify Six2, a developmental transcription factor, as a …

When assembling a nephron during development a multipotent stem cell pool becomes
restricted as differentiation ensues. A faulty differentiation arrest in this process leads to …

The lack of model systems has limited the preclinical discovery and testing of therapies for
Wilms tumor (WT) patients who have poor outcomes. Herein, we establish 45 heterotopic …

Cancer stem cell (CSC) identification relies on transplantation assays of cell subpopulations
sorted from fresh tumor samples. Here, we attempt to bypass limitations of abundant tumor …