Autosomal dominant non-syndromic hearing loss (HL) typically occurs when only one
dominant allele within the disease gene is sufficient to express the phenotype. Therefore …

This article provides a theoretical overview of the association between age-related hearing
loss (ARHL), immune system ageing (immunosenescence), and chronic inflammation …

Age-related hearing loss, or presbyacusis, is a prominent chronic degenerative disorder that
affects many older people. Based on presbyacusis pathology, the degeneration occurs in …

Vestibular schwannoma (VS) is the fourth most common intracranial tumor, arising from
neoplastic Schwann cells of the vestibular nerve and often causing debilitating …

The slow accumulation of inflammatory biomarker levels in the body—also known as
inflammaging—has been linked to a myriad of age-related diseases. Some of these include …

Activation of the NLRP3 inflammasome, a multiprotein complex, leading to caspase
activation with production of proinflammatory IL-1β represents a major pathway of …

Inflammation is involved in noise-induced hearing loss (NIHL), but the mechanism is still
unknown. The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome …

Inflammasomes are large multimeric protein complexes which regulate the activation of the
proinflammatory cytokines interleukins-1β and− 18 and inflammatory cell death called …

The NLRP3 gene mutations are the cause of autosomal dominant autoinflammatory
disorders (NLRP3-AID). Recently, hearing loss (HL) has been found to be the sole or major …

Objectives Gradually progressive sensorineural hearing loss (SNHL) is a prevalent sensory
defect. It is generally untreatable, making rehabilitation by hearing aid or cochlear …