Opioid addiction and overdose are at record levels in the United States. This is driven, in
part, by their widespread prescription for the treatment of pain, which also increased …

Burn injury pain is a significant public health problem. Burn injury treatment has improved
tremendously in recent decades. However, an unintended consequence is that a larger …

This paper is the fortieth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Introduction The aims of this study were to examine whether teeth adjacent and contralateral
to endodontically diseased teeth showed co-occurring mechanical allodynia and to …

Burn victim patients are frequently prescribed opioids at doses that are significantly higher
than standard analgesic dosing guidelines, and, even despite an escalation in opioid …

Social environment influences the trajectory of developing opioid use disorder (OUD). Thus,
the present study tested the hypothesis that sociability levels will affect the responses to …

Abstract μ-Opioid agonists are clinically effective analgesics, but also produce undesirable
effects such as sedation and abuse potential that limit their clinical utility. Glutamatergic …

Background: Opioids are commonly prescribed to treat moderate-to-severe pain. However,
their use can trigger the development of opioid use disorder. A major problem in treating …

Opioids have been utilized for millennia for analgesia, but are accompanied by numerous
adverse effects in addition to their pain relief abilities. These include tolerance, opioid …