Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

The Jackson Laboratory, having the world's largest collection of mouse mutant stocks and
genetically diverse inbred strains, is an ideal place to look for genetically determined eye …

Light exerts widespread effects on physiology and behaviour. As well as the widely-
appreciated role of light in vision, light also plays a critical role in many non-visual …

INTRODUCTION Regenerative therapies based on cell replacement hold promise for the
treatment of a range of age-related degenerative diseases but are limited by unfavorable …

▪ Abstract The neurological mutant mouse reeler has played a critical role in the evolution of
our understanding of normal brain development. From the earliest neuroanatomic studies of …

Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It
has long been assumed that the surviving neural retina is largely resistant to this sensory …

Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss
of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic …

We report the chromosomal localization, mutant gene identification, ophthalmic appearance,
histology, and functional analysis of two new hereditary mouse models of retinal …

A two-trial memory task, based on a free-choice exploration paradigm in a Y-maze, was
previously developed to study recognition processes in Sprague-Dawley rats. Because this …

Over the past 20 years, there has been tremendous progress in retinal gene therapy. The
safety and efficacy results in one early-onset severe blinding disease may lead to the first …