Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in
normal tissues, making most subtypes unsuitable as targets for cancer therapy. However …

Sarcomas are uncommon malignancies of mesenchymal origin that can arise throughout the
human lifespan, at any part of the body. Surgery remains the optimal treatment modality …

Sarcomas are a rare malignancy of mesenchymal tissues, comprizing a plethora of unique
subtypes, with more than 60 types. The sheer heterogeneity of disease phenotype makes …

Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor
outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising …

Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous
system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of …

Triple-negative breast cancer (TNBC), defined as loss of estrogen, progesterone, and Her2
receptors, is a subtype of highly aggressive breast cancer with worse prognosis and poor …

Aberrant expression of glycosphingolipids is a hallmark of cancer cells and is associated
with their malignant properties. Disialylated gangliosides GD2 and GD3 are considered as …

Background Molecular mechanisms underlying inflammation-associated breast tumor
growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to …

All living organisms have developed processes to sense and address environmental
changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour …