Thiazoles and thiazolidinones as COX/LOX inhibitors
K Liaras, M Fesatidou, A Geronikaki - Molecules, 2018 - mdpi.com
Inflammation is a natural process that is connected to various conditions and disorders such
as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase …
as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase …
Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
Synthesis, anticancer activity and molecular modeling studies of 1, 2, 4-triazole derivatives as EGFR inhibitors
HAM El-Sherief, BGM Youssif, SNA Bukhari… - European journal of …, 2018 - Elsevier
A series of novel compounds carrying 1, 2, 4-triazole scaffold were prepared and evaluated
for their antiproliferative activities against NCI 60 cell line. Compounds 10 (a, c), 11 (ad), and …
for their antiproliferative activities against NCI 60 cell line. Compounds 10 (a, c), 11 (ad), and …
Design and synthesis of novel quinoline/chalcone/1, 2, 4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases
New quinoline/chalcone hybrids containing 1, 2, 4-triazole moiety have been designed,
synthesized and their structures elucidated and confirmed by various spectroscopic …
synthesized and their structures elucidated and confirmed by various spectroscopic …
Optimization and SAR investigation of novel 2, 3-dihydropyrazino [1, 2-a] indole-1, 4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent …
Using a single drug to treat cancer with dual-targeting is an unusual approach when
compared to other drug combinations. Dual-targeting agents were developed as a result of …
compared to other drug combinations. Dual-targeting agents were developed as a result of …
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic …
New EGFR inhibitor series of fifteen 5-chloro-3-hydroxymethyl-indole-2-carboxamide
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …
Design and synthesis of novel 2, 3-dihydropyrazino [1, 2-a] indole-1, 4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors
Recent studies have shown additive and synergistic effects associated with the combination
of kinase inhibitors. BRAF V600E and EGFR are attractive targets for many diseases …
of kinase inhibitors. BRAF V600E and EGFR are attractive targets for many diseases …
Structure-based design, synthesis and antiproliferative action of new quinazoline-4-one/chalcone hybrids as EGFR inhibitors
A new series of quinazoline-4-one/chalcone hybrids, 7–26, was synthesized in this study as
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
[HTML][HTML] Thiazole ring-the antimicrobial, anti-inflammatory, and anticancer active scaffold
S Hosseininezhad, A Ramazani - Arabian Journal of Chemistry, 2023 - Elsevier
Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …
Expanding the anticancer potential of 1, 2, 3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases
PA Elzahhar, SM Abd El Wahab, M Elagawany… - European Journal of …, 2020 - Elsevier
Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways
and molecular targets. To that end, a multi-target design strategy was adopted to develop …
and molecular targets. To that end, a multi-target design strategy was adopted to develop …