The pathogenetic role of HLA-B27 and its subtypes
The strong association between HLA-B27 and ankylosing spondylitis has been known for
more than 33 years, but the enigma of the pathogenetic role of the gene and its product has …
more than 33 years, but the enigma of the pathogenetic role of the gene and its product has …
[HTML][HTML] Genetics and functional genomics of spondyloarthritis
Spondyloarthritis (SpA) is a chronic inflammatory disorder with high heritability but with
complex genetics. It encompasses several entities that share common clinical features. Most …
complex genetics. It encompasses several entities that share common clinical features. Most …
Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis
E Jaakkola, I Herzberg, K Laiho… - Annals of the …, 2006 - ard.bmj.com
Objective: To determine the influence of HLA-B27 homozygosity and HLA-DRB1 alleles in
the susceptibility to, and severity of, ankylosing spondylitis in a Finnish population. Methods …
the susceptibility to, and severity of, ankylosing spondylitis in a Finnish population. Methods …
Pathogenesis of ankylosing spondylitis: current concepts
JA Smith, E Märker-Hermann, RA Colbert - Best practice & research …, 2006 - Elsevier
More than three decades after the discovery of HLA-B27 as a major genetic clue to the
origins of ankylosing spondylitis, much has been learned about pathogenesis. However, the …
origins of ankylosing spondylitis, much has been learned about pathogenesis. However, the …
Dual, HLA-B27 subtype-dependent conformation of a self-peptide
M Hülsmeyer, MT Fiorillo, F Bettosini… - The Journal of …, 2004 - rupress.org
The products of the human leukocyte antigen subtypes HLA-B* 2705 and HLA-B* 2709 differ
only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially …
only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially …
HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients
JCC Wei, WC Tsai, HS Lin, CY Tsai, CT Chou - Rheumatology, 2004 - academic.oup.com
Abstract Objectives. Carriage of HLA-B60 has been shown to increase the risk of ankylosing
spondylitis (AS) in B27-positive Caucasian patients, but the association in B27-negative …
spondylitis (AS) in B27-positive Caucasian patients, but the association in B27-negative …
HLA and disease
Association of HLA and diseases is well known. Several population studies are available
suggesting evidence of association of HLAs in more than 40 diseases. HLA found across …
suggesting evidence of association of HLAs in more than 40 diseases. HLA found across …
The interplay between the geographic distribution of HLA-B27 alleles and their role in infectious and autoimmune diseases: a unifying hypothesis
A Mathieu, F Paladini, A Vacca, A Cauli, MT Fiorillo… - Autoimmunity …, 2009 - Elsevier
Due to its strong association with Ankylosing Spondylitis and the other
Spondyloarthropathies, the HLA-B27 family of alleles and, in particular, the ancestral HLA …
Spondyloarthropathies, the HLA-B27 family of alleles and, in particular, the ancestral HLA …
[HTML][HTML] Targeting inflammatory pathways in axial spondyloarthritis
DE Furst, JS Louie - Arthritis research & therapy, 2019 - Springer
The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely
understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin …
understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin …
HLA‑B27 misfolding and spondyloarthropathies
RA Colbert, ML DeLay, G Layh-Schmitt, DP Sowders - Prion, 2009 - Taylor & Francis
HLA‑B27 plays a central role in the pathogenesis of many spondyloarthropathies and in
particular ankylosing spondylitis. The observation that the HLA‑B27 heavy chain has a …
particular ankylosing spondylitis. The observation that the HLA‑B27 heavy chain has a …