Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

Aims: To investigate a possible link between hemodynamic shear stress, reactive oxygen
species (ROS) generation, and proprotein convertase subtilisin/kexin type 9 (PCSK9) …

Background. Neural plasticity may contribute to motor recovery following spinal cord injury
(SCI). In rat models of SCI with respiratory impairment, acute intermittent hypoxia (AIH) …

Ventilatory responses to hypoxia vary widely depending on the pattern and length of hypoxic
exposure. Acute, prolonged, or intermittent hypoxic episodes can increase or decrease …

In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

As in other neural systems, plasticity is a hallmark of the neural system controlling breathing.
One spinal mechanism of respiratory plasticity is phrenic long‐term facilitation (pLTF) …

Intermittent hypoxia (IH) has been extensively studied during the last decade, primarily as a
surrogate model of sleep apnea. However, IH is a much more pervasive phenomenon in …